Chronic abdominal pain sometimes constitute a abdominal pain in both. At this point, clinicians ajor challenge, specially when a patient has two diseasesh dominant featureso daunting task bothin diagnosing and treating anindividual's chronic abdominal pa Similarly, familial Mediterranean fever disease and Crohn's disease have the same clinical features in terms of chronic abdominal pain, inflammatory properties.. and inflammatory properties of these diseases. The association of familial Mediterranean fever disease and Crohn's disease is very rare and may lead to a remarkable challenge in both diagnosis and treatment. Here, we report a young man with FMF disease presented with extraordinary and intolerable abdominal pain relieved only by excessive narcotic analgesics. The presented case was diagnosed with CD and successfully treated with anti-TNF (tumor necrosis factor) due to steroid refractory