People respond differently to difficult life situations. These responses may include feeling trapped, intolerance of uncertainty, negative psychological outcomes, or resilience. Individuals with low mindfulness and limited social connections may struggle more with these processes. Developing psychological resilience is important to cope with and adapt to challenges. This study examined whether intolerance of uncertainty and entrapment mediate the relationship between mindfulness, social connectedness, and psychological resilience. In the present study, it was hypothesized that intolerance of uncertainty and entrapment would play a mediating role in predicting psychological resilience from mindfulness and social connectedness. Data were collected from 351 participants (54 men, 297 women). Mediation analysis was conducted using Structural Equation Modeling (SEM). Results showed that mindfulness and social connectedness negatively predicted intolerance of uncertainty and entrapment, which in turn negatively predicted psychological resilience. Therefore, higher mindfulness and stronger social connections may contribute to greater resilience by reducing feelings of entrapment and fear of uncertainty. The findings suggest that school counselors, parents, and mental health professionals should reinforce social skills and consider mindfulness-based practices to promote psychological resilience.