Plant-based nanoparticles (NPs) synthesis has gained increasing attention due to its costeffectiveness, rapidity, and environmental friendliness. In this study, the green synthesis of silver nanoparticles (MP-AgNPs) using Maclura pomifera fruit extract and their antioxidant activities were investigated. The synthesized MP-AgNPs were characterized by Ultraviolet-Visible (UV-Vis) spectroscopy, Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray Spectroscopy (EDX), Fourier Transform Infrared (FTIR) spectroscopy, and X-ray Diffraction (XRD) analysis. According to the EDX results, the elemental composition by mass was 22.72% carbon, 13.89% oxygen, and 57.74% silver. SEM analysis revealed that the MP-AgNPs were predominantly spherical, with an average particle size of 39.02 nm. The zeta potential of MP-AgNPs was measured as-34.6 mV, indicating good nanoparticle stability and electrostatic repulsion among particles. In antioxidant assays, the ABTS radical scavenging activity showed IC50 values of 6.36 +/- 0.02 mu g/mL for MP-AgNPs, 7.27 +/- 0.00 mu g/mL for BHT, and 10.58 +/- 0.01 mu g/mL for the extract. Furthermore, FRAP assay results demonstrated increased antioxidant activity in the order of extract (3.55 +/- 0.00 mu mol TE/mg), BHT (5.33 +/- 0.01 mu mol TE/mg), and MP-AgNPs (5.39 +/- 0.02 mu mol TE/mg).