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Number of cited
Abstract

Aim: To evaluate intermediate-term therapeutic efficacy and safety outcomes following flow-diverting stent implantation in patients with unruptured intracranial aneurysms. Materials and Methods: A retrospective analysis encompassed consecutive patients treated with flow-diverting devices between April 2021 and April 2025 at our tertiary neurosurgical center. Patient demographics, aneurysm characteristics (location, size, neck width), and treatment variables were collected. Angiographic outcomes were assessed using the O'Kelly-Marotta grading scale at 6, 12, and 24 months post-treatment. Statistical analyses included descriptive statistics, chi-square test for comparing categorical variables, trend analysis, and univariate/multivariate logistic regression to identify predictors of complete occlusion (Grade D). Statistical significance was set at p<0.05. Results: The cohort comprised 64 individuals with 71 unruptured lesions, a mean age of 57.8 +/- 11.5 years, and female predominance (75.0%). Internal carotid territory aneurysms constituted 71.8% of cases, with small-sized lesions (<15mm) representing 64.8%. Technical success was achieved in 97.2% of procedures utilizing Pipeline (59.2%) and Derivo (40.8%) devices. Complete aneurysmal obliteration demonstrated progressive improvement, advancing from 37.3% at six months to 72.6% at twenty-four months (p<0.001). In-stent stenosis (>50%) exhibited a temporal reduction from 7.5% to 3.2% (p=0.048). Favorable neurological outcomes (mRS 0-2) were preserved in >95% of patients throughout follow-up. Mortality occurred in one patient (1.6%) at twenty-four months, with endovascular retreatment required in 6.5% of cases. Discussion: Flow-diverting stent therapy demonstrates progressive aneurysmal healing with acceptable safety profiles for appropriately selected unruptured intracranial aneurysms. The temporal enhancement in occlusion rates coupled with low procedural morbidity supports this endovascular approach, particularly for complex aneurysmal morphologies challenging conventional treatment strategies.

  • Kapsamı

    Uluslararası

  • Type

    Hakemli

  • Index info

    WOS.ESCI

  • Language

    English

  • Article Type

    None