Purpose Multisystem inflammatory syndrome in children emerged as a result of the COVID-19 pandemic and has been reported to cause many different symptoms. We aimed to evaluate the electroencephalographic findings as well as the neurological manifestations of children, followed up with multisystem inflammatory syndrome in children in comparison with healthy controls. Methods Children who were diagnosed with multisystem inflammatory syndrome between March 2020 and 2022 were included. The demographic characteristics of the patients, complaints, electroencephalographic findings, and follow-ups were examined. Results Seventy patients, with a mean age of 108 (+/- 47.7) months and 44 (62.9%) males, were included in the study. Multisystem inflammatory syndrome in children was divided into three categories based on severity:mild ( n =41; 58.5%), moderate ( n =24; 34.2%), and severe ( n =5; 7.1%). At least one neurological symptom was present in 51 (72%) of cases. Table 1 lists the admission grievances. Electroencephalographic recordings were made for all patients in terms of sleep and wakefulness. Electroencephalographic abnormalities were detected in 20 (28.6%) patients ( n =2 generalized and n =18 focal paroxysmal activity). Six weeks later, patients with abnormal electroencephalographic patterns underwent imaging and a control electroencephalography. Generalized epileptiform activity was detected in two patients on electroencephalography, but the patients had normal cranial magnetic resonance imaging and no neurological deficit was found. Of these 20 patients,12 had neurological manifestations, and 8 were asymptomatic. Conclusions This study provides an in-depth evaluation of neurological findings in multisystem inflammatory syndrome in children and includes one of the largest case series on electroencephalographic findings available in the literature. The results highlight the significance of electroencephalographic abnormalities in multisystem inflammatory syndrome in patients, emphasizing the need for close neurological monitoring.