This study focuses on the perspectives of Organic Rankine Cycle (ORC) system integration in & Ccedil;atalagzi Thermal Power Plant (& Ccedil;ATES, Zonguldak, Turkey) to investigate the performance of the plant regarding to energy-exergy analysis, economic analysis, environmental impacts and sustainability. The system analysis of the proposed units were performed under the assumption of various design criteria to improve energy utilization and power generation, where R141b, R123 and R113 were used as working fluids within the ORC. Results showed that the turbine irreversibility decreased 44.6 %, 44.7 % and 44.9 % within our designed ORC plant for working fluids of R141b, R123 and R113, respectively. Among designed ORC plants, R141b configuration leads to minimize waste heat products and R113 configuration leads to minimize exergy destruction rates in turbines and pumps. Thermal efficiency and exergy efficiency of the power plant is increased from 34.5 % to 41.3 % and 32.5-37.6 % for ORC designed plants with R141b, respectively. The lowest environmental effect factor and the highest exergetic sustainability index is determined for ORC plant with R141b configuration that can produce 178 MW of power generation with a profit of 703 million US$ at the end of 30 years. Thus, this study provides insight into the directions of future research on new power plant ORC designs regarding to energy management with exergetic sustainability analysis and economic analysis.