Background ASD impacts not only the person diagnosed with the condition but also the entire family, and the family's life is altered in various ways. The research was carried out to understand the experiences of mothers of children diagnosed with autism spectrum disorder in safeguarding their children's health.Design and Methods In this study, which employed the phenomenological research approach, semi-structured, in-depth interviews were held with 19 individuals who are parents of children diagnosed with autism spectrum disorder in a province located in northern T & uuml;rkiye.Results The data analysis identified five main themes (child health protection practices, mothers' domestic practices, the first thing mothers do when their child is ill, application to health centers and care support in health protection). The sub-themes of adopting a healthy eating routine, choosing clothes suitable for weather conditions, traditional and cultural practices, keeping the house clean, regular sleep, eliminating self-care inadequacy, exercise and movement, and so forth, were determined for child health protection practices. It was revealed that the mothers thought that they were more observant, controlling, and careful to protect their health in a holistic dimension by paying attention to the characteristics of their children.Practice Implications As a result of the study, it was found that mothers of children with autism spectrum disorder exerted greater effort in physical, emotional, and social aspects both inside and outside the home, taking into account their children's specific characteristics to safeguard their health. Awareness of mothers' experiences in protecting the health of a child with ASD is vital in addressing the need for the type of care and support required for children with ASD.