Objective: To compare orbital blood flow parameters in patients having cataract with and without pseudoexfoliation syndrome before and after cataract surgery. Material and Methods: In this prospective study; 54 cases (79 eyes) taken into the study were monitored and treated in the 1st Ophthalmology Clinic and Radiology Clinic, Ataturk Training and Research Hospital. Of those, 31 cases (43 eyes) had cataract and pseudoexfoliation syndrome, 23 cases (36 eyes) had only cataract (control group). Color Doppler imaging was performed to measure ocular blood flow parameters preoperatively and 21 days after cataract operation in each case. Preoperative and postoperative values of resistive indices and pulsatility indices in the ophthalmic, central retinal and posterior ciliary arteries were compared. Results: When compared preoperatively with the control group, cases with pseudoexfoliation syndrome showed no statistically significant difference in the resistivity index values of the ophthalmic artery (0.77 +/- 0.08; P= 0.356), the central retinal artery (0.80 +/- 0.11; P= 0.711) or posterior ciliary arteries (0.79 +/- 0.10; P= 0.097). Preoperative pulsatility index values of patients with pseudoexfoliation syndrom in the ophthalmic artery (1.72 +/- 0.38; P= 0.548), the central retinal artery (1.85 +/- 0.54; P= 0.269), or posterior ciliary arteries (1.81 +/- 0.54; P= 0.074) were not statisticaly significantly different than control group. When compared postperatively with the control group, patients with pseudoexfoliation syndrome showed no statistically significant difference in the resistivity index values of the ophthalmic artery (0.78 +/- 0.07; P= 0.126), the central retinal artery (0.83 +/- 0.08; P= 0.225), posterior ciliary arteries (0.79 +/- 0.10; P=0.496) and in the pulsatility index values of the ophthalmic artery (1.69 +/- 0.38; P=0.356), the central retinal artery (2.05 +/- 0.55; P= 0.364), posterior ciliary arteries (1.74 +/- 0.47; P= 0.393). Cases with pseudoexfoliation syndrome showed no statisticaly significant difference between preoperative and postoperative values of resistive indices and pulsatility indices in the ophthalmic, central retinal and posterior ciliary arteries with the exception of pulsality index of central retinal artery having a higher postoperative (2.05 +/- 0.55) than preoperative (1.85 +/- 0.54) value (P= 0.043). On the other hand, preoperative and postoperative values of resistive indices and pulsatility indices in the ophthalmic, central retinal and posterior ciliary arteries were not significantly different in control group. Conclusion: In patients with pseudoexfoliation syndrome, all studied retroorbital blood flow parameters did not show any significant changes except an increase in postoperative pulsality index in the central retinal artery.