Aim: Indwelling central venous catheters (ICVCs) are indispensable for long-term vascular access, yet their placement is associated with significant complications. Understanding the temporal distribution and risk factors for these complications is crucial for optimizing catheter management. Material and Methods: This retrospective cohort study evaluated 150 patients who underwent ICVC placement between November 2017 and November 2024. Patients were followed for six months to assess early (<= 24 hours) and late (>24 hours) complications. Complications were categorized as thrombotic, infectious, or mechanical. Multivariate analysis was performed to identify independent risk factors influencing adverse outcomes. Results: Complications occurred in 46% of patients, with early events in 12% late complications in 34%. Thrombotic events (13.3%) were the most common late complication, with superior vena cava thrombosis occurring in 12%. Catheter occlusion (5.3%) developed exclusively in the late phase, with 37.5% of cases occurring between 1-2 months and 62.5% beyond 3 months. Subclavian vein catheterization was associated with a significantly higher complication rate (42.0%) compared to internal jugular vein placement (52.3% vs. 79.0%, p<0.001). Diabetes mellitus (p<0.001) and chronic renal failure (p<0.001) were the strongest predictors of catheter-related complications. Discussion: This analysis recalibrates our understanding of ICVC complications, revealing thrombotic sequelae, not infectious events, as the predominant adverse outcomes. The identification of diabetes, renal dysfunction, and subclavian insertion as independently modifiable risk determinants establishes a framework for prophylactic optimization. These findings argue for preferential internal jugular cannulation, enhanced thromboprophylaxis strategies, and intensified surveillance for patients with metabolic and renal comorbidities.