Immigrants may experience many psychosocial problems when migrating from a home to a host country, including social isolation. Social exclusion is also important among the problems experienced by immigrants. This study aims to determine the factors affecting Afghan immigrants' perceived social exclusion in T & uuml;rkiye. Accordingly, a cross-sectional study was conducted on 211 Afghan immigrants (Mage = 30.66, SD = 9), 24% of whom were females. The socio-demographic information form, social exclusion scale, self-esteem rating scale, and life satisfaction scale were used to collect data in this study. The findings showed that Turkish language proficiency, the length of residence in T & uuml;rkiye, working status in T & uuml;rkiye, life satisfaction, and negative self-esteem were predictor factors for social exclusion. Considering the results, suggestions to decision-makers and mental health professionals to reduce the perceived social exclusion of Afghan immigrants are discussed.