Many studies have been conducted on the sources and effects of economic growth and its relationship with various macroeconomic variables. In this study, the relationship between research and development (R&D) expenditures, total factor productivity, and economic growth has been empirically investigated in the case of Turkey. Turkey's 1990-2019 period data and the Granger causality analysis method were used for this purpose. The analysis discovered a one-way causality relationship between R&D expenditures and growth as well as between R&D expenditures and total factor productivity. In this context, Turkey should focus on policies that prioritize R&D and increase R&D expenditures. Furthermore, given that increases in total factor productivity boost growth, policymakers should implement policies that increase resource efficiency and R&D, and encourage the private sector to invest in these areas through tax breaks, financial incentives, and technical assistance.