An estrogen deficiency at menopause induces climacteric symptoms in humans including hot flashes, diaphoresis, sleep disturbances and progressive bone loss. A phytoestrogen can be defined as a plant-derived xenoestrogen molecule with estrogenic activity and not associated with the endocrine system. The present study aims to investigate the chemical constituents and their potency as a phytoestrogen of chestnut-honey based propolis from Carsamba district (Samsun, Turkey) by in silico molecular docking simulation.,The present study evidenced the phenolic constituents from chestnut-honey based propolis possess phytoestrogen activity.