Whole-body electrical myostimulation is an alternative exercise training method. The effects of this exercise program on hemodynamics and coronary circulation have recently been investigated. However, an acute coronary syndrome associated with whole-body electrical myostimulation has not been reported before. In this case report, we present a patient who underwent whole-body electrical myostimulation in a sports center for weight control and was admitted to the emergency department with chest pain started in the second session of the training. Her electrocardiogram showed ischemic T-wave changes in the inferior leads. Additionally, troponin levels were elevated. A coronary angiogram was performed with the diagnosis of non-ST--segment elevation myocardial infarction. The coronary angiogram revealed severe vasospasm in the right coronary artery, which resolved with intracoronary nitroglycerin. She was uneventfully discharged with medical treatment. This case report is the first patient with acute coronary syndrome associated with whole-body electrical myostimulation in the literature.