Aim To investigate the level of cyberchondria in patients with high-risk human papilloma virus (HPV) positivity. Methods One hundred and forty women who applied to our clinic between July 2020 and September 2020 and were diagnosed with high-risk HPV positivity or abnormal uterine bleeding (AUB) were included in the study. The Cyberchondria Severity Scale (CSS) was administered face-to-face to the participants. CSS and subscales scores of both groups of patients were evaluated and compared. Results The mean score of the patients on the CSS was 78.54 +/- 22.09 and the patients with AUB and HPV(+) was 67.43 +/- 19.87 and 84.16 +/- 21.08, respectively. The mean subscale scores were as follows, compulsion 13.89 +/- 6.49, distress 20.07 +/- 7.54, excessiveness 22.40 +/- 8.18, reassurance 15.07 +/- 6.56, and mistrust of medical professionals 7.26 +/- 3.62. The mean scores of the CSS and subscales except for the mistrust of medical professional subscale were higher in patients who were HPV-positive than in other patients. Conclusions Women with HPV have higher levels of cyberchondria. Medical professionals can reduce this anxiety by giving information to patients.