This study examines the predictive roles of university students' life satisfaction and communication skills on their motivation. The participants of this study include 603 undergraduate students. Of the participants, 435 are female, 168 are male, and the mean age is 20.2 years. Students' GPA averages range from 1.87 to 3.91 on a 4.0 scale. The data were collected through three data collection instruments. A multiple regression analysis was employed to find out the relationships between all of the variables, and examining the predictive roles of independent variables on the dependent variable. The findings show that there is a positive and meaningful relationship between life satisfaction, communication skills, and motivation of university students. The highest correlation was found between motivation and respect, which is a dimension of communication skills. The findings also indicate that the participants' life satisfaction and communication skills explain the variances of students' motivation. The highest predictor of motivation among all dimensions is respect, as it explains the variances by 16.6%.