Abstract
A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolar cycloaddition reactions of alpha-aryl-N-methyl nitrones with diethyl maleate. The structures of the synthesized compounds were characterized using spectroscopic methods. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against a yeast strain. The results show that all the synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B. cereus, B. abortus and C. albicans when compared to standard drugs.
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Kapsamı
Uluslararası
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Type
Hakemli
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Index info
WOS.ESCI
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Language
English
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Article Type
None
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Keywords
Isoxazolidine Nitrone 1 3-Dipolar cycloaddition reaction Antimicrobial activity