Purpose: This study aimed to evaluate the value of neutrophil/lymphocyte ratio (NLR) together with the demographic characteristics in predicting liver insufficiency or transplantation need following mushroom poisoning.,Materials and Methods: The patients were evaluated in terms of various parameters including gender, age, the month of admission, symptoms on emergency service admission, vital findings, laboratory findings, poisoning severity score (PSS) according to initial symptoms, and onset time of symptoms. The patients were divided into two groups according to whether the liver function tests were deteriorated or not. NLR was assessed according to PSS in patients with and without acute liver failure.,Results: A total of 84 patients, aged 16-85 years, were included in the study. Neutrophil/lymphocyte ratio was 10.82 +/- 8.7 in patients with impaired liver function tests and statistically significant compared to the patients with normal liver function tests (5.66 +/- 4.71). NLR was statistically significantly higher in patients who developed acute liver failure and in those with high poisoning severity score. The cut-off value was founded as 9.65.,Conclusion: NLR may be a useful predictor of liver failure or transplantation need, which develops as a result of mushroom poisoning.