Abstract
A new derivate of 4-bromo-1,8-naphthalic anhydride and its quaternized analogue have been prepared and characterized. The interactions of both derivatives with human telomere quadruplex-DNA and ds-DNA have been comparatively studied by UV-visible (UV-Vis), fluorescent intercalator displacement assays, competition dialysis, circular dichroism (CD), agarose gel electrophoresis, and polyacrylamide gel electrophoresis. The results show that both derivatives can stabilize G-quadruplexes DNA, and they show different binding affinities for G-quadruplexes-DNA and ds-DNA. All spectroscopic studies have shown that the derivatives have a modest selectivity for G-quadruplex versus ds-DNA.
-
Kapsamı
Uluslararası
-
Type
Hakemli
-
Index info
WOS.SCI
-
Language
English
-
Article Type
None
-
Keywords
4-Bromo-1 8-naphthalic anhydride Quaternized Naphthalimide DNA binding G-Quadruplex DNA selectivity