OBJECTIVE,To date, several methods have been identified for predicting the prognostic subgroups of grade II gliomas; however, these methods have some limitations in predicting survival. So, we aimed to determine the predictive role of Ki-67 labeling, index (LI) on survival.,METHODS,Between 1995 and 2011, patients with grade II, gliomas were retrospectively analyzed. All patients received radiotherapy (RT).,RESULTS,This study included 78 patients with median 44 (range, 6-137) months follow-up. Patients aged >= 40 years had a poorer overall survival (OS) than those aged <10 years (p=0.04). Patients with gross total resection/ subtotal resection had a longer OS than those with biopsy/partial resection (p=0.001). If the disease had recurrence or progression during the follow-up period, the patients had a poorer OS (p=0.01). Patients with a Ki-67 LI >= 4% had a poorer OS than those with Ki-67 LI < 4%(p=0.001). The extent of resection, recurrence, or progression, and Ki-67 LI >= 4% were the independent prognostic factors for OS.,CONCLUSION,In our opinion, Ki-67 LI is an important prognostic factor for grade II gliomas, hut it cannot be used as a diagnostic measure alone. It must be used in combination with the other prognostic factors.