Objective: To investigate patient-and procedure-related factors associated with hospital re-admission following urethral manipulations for the treatment of urethral strictures.,Materials and Methods: Data of patients who underwent dilation or internal urethrotomy for urethral strictures between 2011 and 2016 were retrospectively analyzed. Patients who were admitted to our institute for any reason within one month after hospital discharge were evaluated. The patient-and procedure-related factors affecting the readmission rates were revealed by multiple binary logistic regression using stepwise backward elinimination.,Results: The average age of 76 male patients was 61.7 +/- 14.4 years. The mean maximal flow rate at preoperative uroflowmetry was 6.01 +/- 4.3 and the median American Society of Anesthesiologists score was 2.38. The process was the first for 45 (59.2%) patients, the second for 16 (21.1%) patients, the third for 9 (11.8%) patients, and the fourth for 6 (7.9%) patients. Amplatz dilators, cold knife and Ho: YAG laser were used in 50%, 27.6% and 22.4% of patients, respectively. The mean length of hospital stay was 0.89 +/- 0.31 days, and the complication rate was 19.7% (15/76). The mean urethral catheter dwell time was 8.9 +/- 14.2 day. Overall, the procedure was successful in 61 (80.3%) patients and failed (Q(max) < 15 mL/sec) in 19.7% of the cases. Fifteen (19.7%) patients were re-admitted, while 2 (2.6%) patients among them were re-hospitalized for further treatment. Comorbidity and age were independent predictors of re-admission.,Conclusion: We found that younger age and lower comorbidities predicted hospital re-admission following procedures for urethral strictures.