Investigation of pre-equilibrium (PEQ) and equilibrium (EQ) effects on proton induced reactions for production of radioisotopes are very important. Therefore, in this study, we have calculated the PEQ and EQ cross-sections for Zn-67(p,n)Ga-67, Zn-68(p,2n)Ga-67, Kr-82(p,2n)Rb-81, Cd-111(p,n)In-111, Cd-112(p,2n)In-111, Te-123(p,n)I-123, Te-124(p,2n)I-123, Te-124(p,n)I-124 and Xe-124(p,2n)Cs-123 reactions for production diagnostic radioisotopes. Calculations have been performed by using the hybrid model, geometry dependent hybrid model and full exciton model of PEQ reaction mechanism with 1-40 MeV proton incident energy. We have also investigated the EQ effects on these reactions using the Weisskopf-Ewing model in the same energy range. The excitation functions including the PEQ and EQ effects on these reactions are evaluated by using the ALICE/ASH (2006) and the TALYS 1.4 (2011) codes. Our results have shown that using these codes is suitable for production diagnostic isotopes mentioned above. To obtain excitation functions for producing the diagnostic radioisotopes the PEQ mechanism has been found more dominant than that of the EQ. The results are discussed and compared with the available experimental data.