A 57-year-old female with obesity was admitted to the emergency service with the complaint of severe dyspnea and chest pain. Chest X-ray showed opacity occupying left hemithorax completely and the right mediastinal shift. Thoracic computed tomography indicated a heterogeneous density of a giant mass in the left hemithorax and right mediastinal shift. Complete surgical resection of the liposarcoma was performed. The pathological examination following surgery suggested pleural liposarcoma. In this article, treatment of pleural liposarcoma was discussed in the light of literature review.