Study Objective: To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations.,Design: Randomized. placebo-controlled study.,Setting: Univesity medical center.,Patients: 80 ASA physical status I and II patients, aged 18 to 05 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations.,Interventions: Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus close of one mu g kg(-1), then intraoperative maintenance was supplied with dexmedetomidine 0.7 mu g kg(-1) hour(-1). Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one mu g kg(-1) was given.,Measurements: Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded.,Main Results: Group SI) had less bleeding and lower bleeding scores (P < 0.05). In addition, this group received less intraoperative fentanyl (P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 +/- 58.8 vs 110.0 +/- 81.0 mu g) (P < 0.05).,Conclusion: Dexmedetomidine reduces bleeding, bleeding, scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations. (C) 2008 Elsevier Inc. All rights reserved.