Background/Aims. The aim of this study was to identify oxidative damage of kidney during ischemia reperfusion injury ORI) by evaluating changes in lipid peroxidation markers in tissue and blood kit an experimental model. Oxidized LDL (ox-LDL) was used as an oxidative stress biomarker, whereas paraoxonase (PON-1) activity was used as an antioxidative biomarker. Methods. Sixty-three male Wistar rats were randomly assigned into dime groups: renal IRI, sham, and control. In the renal HU group, the right kidney was removed and the artery and vein of the left kidney were clamped for 90 minutes. The presence of ox-LDL in the kidney tissue sections was determined by using an immunofluorescent staining method. Results. The plasma ox-LDL levels did not increase significand at the 24(th) hour following IRI, made a peak at the 48(th) hour, ind declined at the 72(nd) hour. Accumulation of ox-LDL was detected in the kidney tissue on the 24(th), 48(th), and 72(nd) hours of the renal I RI. Serum PON-1 levels have peaked on the 24th hour and then declined. Conclusion. This study demonstrates the accumulation of ox-LDL molecules in the renal tissues of the IRI model. Future strategies aimed to reduce the lipid peroxidation during the initial hours of renal IRI may be useful to prevent complications of ischemia.